Platelet GPVI Mouse anti-Human, PE, Clone: HY101, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565241

Catalog No. BDB565241

Description

The HY101 monoclonal antibody specifically binds to a collagen receptor, Platelet Glycoprotein VI (GPVI or GP6). GPVI is a 58-kD platelet membrane glycoprotein that belongs to the immunoglobulin superfamily. Upon blood vessel wall injury and consequent endothelial cell damage, platelets collect upon the exposed collagen fibers present in the subendothelial matrix. The platelet and collagen interaction leads to activated platelet aggregation and thrombus formation. Although normally serving a protective function in clot formation that limits blood loss, the platelet GPVI/collagen interaction may also play a role in myocardial infarction and stroke which are associated with the rupture of atherosclerotic plaques.

Specifications

• Antigen: Platelet GPVI
• Clone: HY101
• Description: Glycoprotein 6; GP6; Platelet glycoprotein VI; Platelet collagen receptor
• Format: Affinity purified
• Immunogen: Glycoprotein VI Recombinant Protein
• Quantity: 50 Tests
• Storage Requirements: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry
• Conjugate: PE
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide
• Host Species: Murine
• Isotype: IgG₁, κ
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human