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MilliporeSigma™ anti-Plk1 Clone: 35-206,

Catalog No. DR103750UG Shop All MilliporeSigma Products
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Quantity:
50 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
DR103750UG 50 μg Unconjugated
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Catalog No. DR103750UG Supplier MilliporeSigma™ Supplier No. DR103750UG

Description

Mouse Monoclonal Antibody

Specifically detects Plk1 Clone: 35-206 in Human, Mouse, Rat samples, and it is validated for Immunoprecipitation

Plk1 (ACC# NP_005021) is an evolutionarily conserved member of the polo-like serine/threonine kinase family that plays a critical role in spindle formation, chromosome segregation, regulation of the anaphase-promoting complex (APC), and execution of cytokinesis. Predominantly cytoplasmic during interphase, Plk1 is associated with condensed chromatin during mitosis when its kinase activity peaks. Plk1 regulates mitotic events through phosphorylation of its substrates Cdc25, the activator of Cdc2, and Cdc27, a component of the APC. Phosphorylation of Cdc25C by Plk1 is thought to lead to nuclear accumulation of Cdc25 and activation of Cdc2. Phosphorylation of Cdc27 leads to destruction of the APC. Ectopic expression of Plk1 in NIH3T3 leads to transformation. Over-expression of Plk1 is positively correlated with aggressiveness and prognosis of many cancers and inhibition of Plk1 activity results in growth arrest and apoptosis in cancer cells. Plk1 has been shown to be elevated in numerous cancers including lung, breast, ovarian, melanoma, colorectal, and gliomas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Plk1
Applications Immunoprecipitation
Classification Monoclonal
Clone 35-206
Conjugate Unconjugated
Formulation In PBS.
Host Species Mouse
Immunogen full-length, recombinant, human Plk1
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽62kDa Plk1 protein in HeLa cells.
Target Species Human, Mouse, Rat
Content And Storage −20°C
Form Purified
Isotype IgG2b
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