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PLK1 (pT210) Mouse, Unlabeled, Clone: K50-483, BD

Catalog No. BDB558400 Shop All BD Biosciences Products
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Catalog No. BDB558400 Supplier BD Biosciences Supplier No. 558400
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Mouse Monoclonal Antibody

Polo-like kinase (PLK1) is a serine/threonine kinase with structural similarities to Drosophila's Polo kinase and the Cdc5p of Saccharomyces cerevisiae. Like its invertebrate counterparts, PLK1 activity is required for DNA synthesis and is regulated throughout the cell cycle. Furthermore, PLK1 is highly expressed in primary tumors. It associates with the mitotic spindle during mitosis suggesting that, in addition to its role during S phase, PLK1 may play a role during chromosome segregation. This is consistent with its potential role in cancer development. Threonine 210 (T210) is one of the major phoshorylation sites in activated PLK1 obtained from human mitotic cells. The K50-483 monoclonal antibody recognizes the phosphorylated T210 of human PLK1.

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen PLK1 (pT210)
Applications Western Blot
Classification Monoclonal
Clone K50-483
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human PLK1 Peptide
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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For Research Use Only.

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