PPAPDC2 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112769
A suggested positive control for this product is testislysate.Upon cell activation Presqualene diphosphate (PSDP)2, a bioactive lipid, rapidly remodels to presqualene monophosphate (PSMP). A newly identified and characterized phosphatase (phosphatidic acid phosphatase domain containing 2 (PPAPDC2)) has recent;y been shown to convert PSDP to PSMP. Unlike the related polyisoprenyl phosphate farnesyl diphosphate (FDP), PSDP has been shown not to be a substrate for type 2 lipid phosphate phosphohydrolases. PSDP phosphatase activity has been identified in activated human neutrophil (PMN) extracts. Recombit PPAPDC2 displays diphosphate phosphatase activity with substrate preference for PSDP > FDP phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and optimal at pH 7.0–8.0. PPAPDC2 mRNA has been detected in human PMN, and is widely expressed in human tissues. PPAPDC2 expressed inhuman PMN is first lipid phosphate phosphohydrolase identifiedfor PSDP. The regulation of this enzyme’s activity has importantimplications for PMN activation in innate immunity.
|PBS with 0.1% BSA and 0.08% sodium azide|
|RP11-6J24.2, FLJ46512, FLJ90191, MGC15483, PSDP, bA6J24.6|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunoprecipitation, Western Blot|
|Synthetic peptide corresponding to human phosphatidic acid phosphatase type 2 domain containing 2 (PPAPDC2).|
|Antigen affinity chromatography|
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