peroxisome proliferator-activated receptor delta, Mouse, Clone: 1G4, Abnova™

Catalog No.	Quantity
89-000-890	100 μg

Catalog No. 89-000-890 Supplier Abnova Corporation Supplier No. H00005467M03

Description

Mouse monoclonal antibody raised against a partial recombinant PPARD.

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq

Sequence: DQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG

Specifications

• Antigen: peroxisome proliferator-activated receptor delta
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 1G4
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a partial recombinant PPARD.
• Formulation: PBS with no preservative; pH 7.4
• Gene: PPARD
• Gene Accession No.: NM_006238
• Gene Alias: FAAR/MGC3931/NR1C2/NUC1/NUCI/NUCII/PPAR-beta/PPARB
• Gene Symbols: PPARD
• Host Species: Mouse
• Immunogen: PPARD (NP_006229, 56 a.a. ∼ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Transcription Regulation
• Whole Molecule: Yes
• Primary or Secondary: Primary
• Gene ID (Entrez): 5467
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Isotype: IgG1 κ