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Pre-B Cell Receptor Rat anti-Mouse, Biotin, Clone: SL156, BD

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BDB551863 0.1 mg
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Catalog No. BDB551863 Supplier BD Biosciences Supplier No. 551863
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Description

Rat Monoclonal Antibody

The pre-B cell receptor (pre-BCR) expressed during the early stages of B lymphocyte development is a heterodimer of immunoglobulin heavy chain (IgH) with surrogate light chain, which is an Ig-light-chain-like molecule composed of the non-covalently linked Lambda 5 (λ5) and VpreB proteins. The pre-BCR is believed to control IgH repertoire selection and proliferation of differentiating B lymphocytes. The SL156 antibody reacts with a conformational epitope of the pre-BCR in transfected X63-Ag8.653 cells but not with surrogate light chain, λ5, or VpreB in the absence of IgH. It detects pre-BCR on pre-B cell lines, but not on pro-B cell lines or IgM-positive splenocytes. It also detects pre-BCR on the surface of pre-B cells, but not on Ig light chain (IgL)-positive B lymphocytes, from the bone marrow of normal mice. It has been noted that the cell-surface expression of pre-BCR is upregulated after a one-hour incubation of bone-marrow leukocytes in tissue culture medium at 37°C. After immunization, cell-surface pre-BCR is detected on a subset of splenic IgL+ germinal-center B lymphocytes.

Host Species: Rat
Clone: SL156
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Purified soluble complex of recombinant μ IgH, λ5, and VpreB

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen Pre-B Cell Receptor
Applications Flow Cytometry
Classification Monoclonal
Clone SL156
Concentration 0.5mg/mL
Conjugate Biotin
Description Pre-BCR
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Purified soluble complex of recombinant μ IgH, λ5, and VpreB
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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For Research Use Only.

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