Pre-T Cell Receptor α Chain Mouse anti-Mouse, Unlabeled, Clone: 2F5, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 552407

Catalog No. BDB552407

Description

At very early stages in the intrathymic differentiation of T lymphocytes which will bear αβ T Cell Receptors (TCR), the TCR β chain forms a heterodimer with the pre-TCR α chain (pTα) to form the pre-TCR. This pre-TCR associates with the signal-transducing CD3 complex and controls the survival and proliferation of CD4- CD8- (DN) thymocytes, plays a role in allelic exclusion of the TCR β chain, directly or indirectly regulates TCR δ chain expression, and is eventually replaced by the TCR α chain as thymocytes mature. The 2F5 antibody reacts with the PTα on the surface of CD44- CD25-/lo DN thymocytes.

Host Species: Mouse
Clone: 2F5
Isotype: IgG1 κ
Species Reactivity: Mouse
Immunogen: Recombinant extracellular (Ig-like) domain of pTα

Flow Cytometry, Immunoprecipitation

Specifications

• Antigen: Pre-T Cell Receptor α Chain
• Classification: Monoclonal
• Concentration: 0.5mg/mL
• Description: pTα
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C

• Applications: Flow Cytometry
• Clone: 2F5
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Immunogen: Recombinant extracellular (Ig-like) domain of pTα
• Quantity: 0.1 mg
• Research Discipline: Immunology
• Target Species: Mouse
• Isotype: IgG1 κ

For Research Use Only.