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PEN2 Rabbit anti-Bovine, Canine, Equine, Human, Marsupial, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523447

Catalog No. PIPA523447


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Description

Description

Presenilin enhancer protein 2 (PEN-2) is a part of a gamma-secreted complex which catalyses the final cleavage of amyloid precursor protein to generate the toxic amyloid beta protein, the major component of plaque in the brains of Alzheimer disease patients. It is an essential subunit of the gamma-secretase complex, and an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). And probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Specifications

Specifications

PEN2
Polyclonal
Unconjugated
PSENEN
Liquid
PSENEN
Synthetic peptide (2 NLERVSNEEKLNLCRKYY 19) of Presenilin enhancer protein 2 protein.
Protein A
RUO
Antibody
Polyclonal
Bovine, Canine, Equine, Human, Marsupial, Mouse, Rat
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q5G235, Q9NZ42, Q9CQR7, Q6QI68
MDS033, MSTP064, PEN-2, PEN2, gamma-secretase subunit PEN-2, hematopoietic stem/progenitor cells protein MDS033
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100051536, 292788, 476479, 493993, 55851, 66340
Documents
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