PEN2 Rabbit anti-Bovine, Canine, Equine, Human, Marsupial, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523447
DescriptionPresenilin enhancer protein 2 (PEN-2) is a part of a gamma-secreted complex which catalyses the final cleavage of amyloid precursor protein to generate the toxic amyloid beta protein, the major component of plaque in the brains of Alzheimer disease patients. It is an essential subunit of the gamma-secretase complex, and an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). And probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
|Synthetic peptide (2 NLERVSNEEKLNLCRKYY 19) of Presenilin enhancer protein 2 protein.|
|Bovine, Canine, Equine, Human, Marsupial, Mouse, Rat|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Q5G235, Q9NZ42, Q9CQR7, Q6QI68|
|MDS033, MSTP064, PEN-2, PEN2, gamma-secretase subunit PEN-2, hematopoietic stem/progenitor cells protein MDS033|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100051536, 292788, 476479, 493993, 55851, 66340|
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