PRKAR1A, Rabbit, Monoclonal Antibody, Abnova™

Catalog No.	Quantity
89-200-139	1 mg x up to 3 Abs

Catalog No. 89-200-139 Supplier Abnova Corporation Supplier No. H00005573K

Description

Includes

Up to three rabbit IgG clones of 1mg each will be delivered to customer.

Rabbit monoclonal antibody raised against a human PRKAR1A peptide using ARM Technology.

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq

Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)
Expression: Overexpression vector and transfection into 293H cell line

Order Info

1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.

Specifications

• Antigen: PRKAR1A
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Concentration: 1mg
• Conjugate: Unconjugated
• Description: protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
• Formulation: In 1X PBS, pH 7.4
• Gene: PRKAR1A
• Gene Accession No.: PRKAR1A
• Gene Alias: CAR, CNC, CNC1, DKFZp779L0468, MGC17251, PKR1, PPNAD1, PRKAR1, TSE1
• Gene Symbols: PRKAR1A
• Host Species: Rabbit
• Immunogen: A synthetic peptide of human PRKAR1A
• Quantity: 1 mg x up to 3 Abs
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5573
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG