PSD-95 Mouse, Unlabeled, Clone: 16, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610496

Catalog No. BDB610496

Description

PostSynaptic Density (PSD) refers to a dense region of submembranous cytoskeleton found most prominently in postsynaptic membranes of the CNS. Possible functions for the PSD include regulation and aggregation of receptors,structural stabilization of the synaptic junction, and transduction of signals from membrane receptors. Some of the proteins associated with the PSD are fodrin, tubulin, calmodulin, CaM Kinase II, PSD-95, and PSD-93. PSD-95 (SAP90) is a protein that interacts with the NMDA receptor NMDAR2B, neuronal NOS(nNOS or bNOS), and other proteins. PSD-95 contains one SH3 domain in its carboxy-terminal domain, as well as three conserved repeat regions called GLGF or PDZ domains. nNOS, which is concentrated in synaptic junctions, also contains a PZD domain. PSD-95 and nNOS interact via their respective PZD domains, which may mediate the binding of nNOS to skeletal muscle syntrophin.

This antibody is routinely tested by western blot analysis. Other applications were tested in BD Biosciences Pharmingen during antibody development only or reported in the literature.

Specifications

• Antigen: PSD-95
• Clone: 16
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Host Species: Murine
• Isotype: IgG₁
• Regulatory Status: RUO
• Storage Requirements: Store undiluted at -20°C.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Western Blot
• Concentration: 250μg/mL
• Description: PostSynaptic Density-95; SAP90
• Format: Affinity Purified
• Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Quantity: 150μg
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Murine, Rat

For Research Use Only.