MilliporeSigma™ anti-PSD-95 Clone: 7E3-1B8,

Catalog No.	Quantity	Conjugate
CP35100UL	100 μL	Unconjugated

Catalog No. CP35100UL Supplier MilliporeSigma™ Supplier No. CP35100UL

Description

Mouse Monoclonal Antibody

Specifically detects PSD-95 Clone: 7E3-1B8 in Rat samples, and it is validated for Immunofluorescence, Immunoprecipitation

Effective synaptic transmission requires the precise distribution and spatial localization of neurotransmitter receptors and ion channels on the postsynaptic nerve terminal. An understanding of synaptic development is derived largely from studies of the vertebrate skeletal neuromuscular junction. At glutamatergic synapses, the membrane associated cytoskeletal protein PSD-95 (Post Synaptic Density 95kDa) is believed to promote receptor clustering via interactions with the NR2 subunit of the NMDA receptor and the Shaker-type potassium channel. These interactions are likely mediated by multiple repeating PDZ domains (90 amino acid repeats). Two additional proteins, homer and GRIP, have recently been shown to interact with the metabotropic and AMPA receptors, respectively. It is likely that these proteins serve major functions in the molecular scaffolding and signal transduction process, which occurs at the synaptic junction.

Specifications

• Antigen: PSD-95
• Applications: Immunofluorescence, Immunoprecipitation
• Classification: Monoclonal
• Clone: 7E3-1B8
• Conjugate: Unconjugated
• Formulation: In PBS.
• Host Species: Mouse
• Immunogen: recombinant, rat PSD95
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽95kDa PSD95 protein.
• Target Species: Rat
• Content And Storage: −20°C
• Form: Purified
• Isotype: IgG2a

For Research Use Only