presenilin 1, Mouse, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-018-838	50 μL

Catalog No. 89-018-838 Supplier Abnova Corporation Supplier No. H00005663A01

Description

Mouse polyclonal antibody raised against a partial recombinant PSEN1.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq]

Sequence: PALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGL

Specifications

• Antigen: presenilin 1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Mouse polyclonal antibody raised against a partial recombinant PSEN1.
• Formulation: 50% glycerol
• Gene: PSEN1
• Gene Accession No.: BC011729
• Gene Alias: AD3/FAD/PS1/S182
• Gene Symbols: PSEN1
• Host Species: Mouse
• Immunogen: PSEN1 (AAH11729, 280 a.a. ∼ 379 a.a) partial recombinant protein with GST tag.
• Quantity: 50 μL
• Regulatory Status: RUO
• Research Discipline: Apoptosis
• Primary or Secondary: Primary
• Gene ID (Entrez): 5663
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Serum