proteasome (prosome, macropain) subunit, alpha type, 7, Mouse, Clone: 1A10-3G12, Abnova™

Catalog No.	Quantity
89-015-838	100 μg

Catalog No. 89-015-838 Supplier Abnova Corporation Supplier No. H00005688M01

Description

Mouse monoclonal antibody raised against a full-length recombinant PSMA7.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 nonidentical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a nonlysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9. [provided by RefSeq

Sequence: MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENEKKKQKKAS

Specifications

• Antigen: proteasome (prosome, macropain) subunit, alpha type, 7
• Applications: ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 1A10-3G12
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against a full length recombinant PSMA7.
• Formulation: PBS with no preservative; pH 7.4
• Gene: PSMA7
• Gene Accession No.: BC004427
• Gene Alias: C6/HSPC/MGC3755/RC6-1/XAPC7
• Gene Symbols: PSMA7
• Host Species: Mouse
• Immunogen: PSMA7 (AAH04427, 1 a.a. ∼ 248 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Ubiquitin/Proteasome
• Primary or Secondary: Primary
• Gene ID (Entrez): 5688
• Target Species: Human
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Isotype: IgG2b κ