proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 (B01), Mouse anti-Human, Polyclonal Antibody, Abnova
Mouse polyclonal antibody raised against a full-length human PSMD8 protein.
Manufacturer: Abnova Corporation H00005714B01
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 nonidentical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a nonlysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeqSequence: MYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
|proteasome (prosome, macropain) 26S subunit, non-ATPase, 8|
|Mouse polyclonal antibody raised against a full-length human PSMD8 protein.|
|PSMD8 (NP_002803, 1 a.a. ~ 257 a.a) full-length human protein.|
|Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
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