Psme3/PA28-γ Mouse, Unlabeled, Clone: 47, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611180
The 20S proteasome is the major constituent of the proteasomal complex that mediates degradation events, including the generation of antigenic peptides that interact with MHC class I. The 20S proteasome is a cylindrical shaped complex composed of four layers of rings, each with seven subunits. The inner rings contain α-subunits, while the outer rings contain β-catalytic subunits. The constituents of the PA28 activator complex are additional subunits with specialized roles in class I-mediated antigen presentation. PA28 is a ring-shaped structure with alternating α- and β-subunits. This complex binds the α-rings of 20S and stimulates its activity. Expression of the PA28 α- and β-subunits is strongly induced by IFN-γ. The protein product of the Psme3 gene, also known as the Ki antigen, is highly homologous to the PA28 α- and β-subunits and has been designated the PA28 γ-subunit. This protein forms a homohexamer that binds the 20S proteasome and is thought to modulate proteasome activity. The PA28 α- and β-subunits are located in the cytoplasm and in the nucleus, while the γ-subunit is almost exclusively nuclear.
Host Species: Mouse
Species Reactivity: Rat
Immunogen: Mouse Psme3/PA28-γ aa. 45-147
Formula Weight [Chemical]: 36kDa
Immunofluorescence, Western Blotting
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Mouse Psme3/PA28-γ aa. 45-147|
|Canine, Human, Murine, Rat|
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