PTEN Mouse, Unlabeled, Clone: A2B1, BD

Catalog No.	Quantity
BDB559600	0.1 mg

Catalog No. BDB559600 Supplier BD Biosciences Supplier No. 559600

Description

Mouse Monoclonal Antibody

Cancer can develop when cells escape normal growth control mechanisms through mutations in proto-oncogenes or tumor suppressor genes. A characteristic of most oncogene and tumor suppressor gene products is that they are components of signal transduction pathways that are essential for maintaining cellular homeostasis. PTEN (phosphatase and tensin homolog detected on chromosome ten/MMAC or TEP1 (mutated in multiple advanced cancers) is a tumor suppressor gene that has been identified as mutated in multiple tumor types. PTEN is a phosphatase that acts on proteins and lipid second messengers. The ability of PTEN to cause tumors is thought to result from the loss of its negative control on the phosphoinositide 3-kinase signaling pathway which regulates cell growth and survival. Using a mutant mouse model for PTEN, Suzuki et al. demonstrated that these mice had elevated levels of the protein kinase Akt in tumors associated with loss of heterozygosity of mPTEN. Human PTEN is a polypeptide of 403 amino acids based on the nucleotide sequence and is observed to migrate at ∽55kDa in SDS/PAGE. The antibody recognizes human and mouse PTEN. A peptide representing amino acids 387-400 at the C-terminus of human PTEN was used as the immunogen.

Western Blotting

Specifications

• Antigen: PTEN
• Applications: Western Blot
• Classification: Monoclonal
• Clone: A2B1
• Concentration: 0.5mg/mL
• Conjugate: Unconjugated
• Description: MMAC1, TEP1
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Human PTEN peptide aa. 387-400
• Purification Method: Affinity Purified
• Quantity: 0.1 mg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Content And Storage: Store undiluted at 4°C
• Isotype: IgG1 κ