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anti-PTEN/MMAC1 Ab-3, Clone: 10P03; same as A5, Epredia™ LabVision

Catalog No. MS1250PCL Shop All Epredia Products
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MS1250PCL 100 μL
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Description

Mouse Monoclonal Antibody

PTEN/MMAC1, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling.

Host Species: Mouse
Clone: 10P03; same as A5
Isotype: IgG1/κ
Cross Reactivity: Human and Mouse. Others-not known.
Epitope: aa 388-400
Immunogen: A synthetic peptide corresponding to aa 388-400 (ENEPFDEDQHTQI) from the C-terminus of human PTEN
Molecular Weight: 60kDa
Positive Control: A431, NIH-3T3 cells
Cellular Localization: Cytoplasmic

Immunofluorescence, Immunoprecipitation, Western Blotting

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Antigen PTEN/MMAC1 Ab-3
Classification Monoclonal
Clone 10P03; same as A5
Concentration 250μg/100μL
Conjugate Unconjugated
Host Species Mouse
Quantity 100 μL
Primary or Secondary Primary
Target Species Human, Mouse
Isotype IgG1 κ
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