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PU.1 Mouse anti-Human, Unlabeled, Clone: G148-74, BD

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Description

Mouse Monoclonal Antibody

PU.1 is an ets-related transcription factor expressed in B lymphocytes and macrophages. It was initially identified as the oncogene Spi-1 which was found to block erythroblast differentiation. PU.1 functions by binding transcriptional control elements such as μB in the immunoglobulin heavy chain enhancer and π adjacent to μE2. It has been shown to form a complex with NF-EM5, a B cell transcription factor, resulting in the activation of the immunoglobulin κ 3' enhancer. PU.1 also appears to be critically involved in the control of monocyte development by regulating the expression of the macrophage colony-stimulating factor receptor. PU.1 runs as a 40-42kDa protein on SDS-PAGE. G148-74 recognizes human PU.1, an Ets-related transcription factor. PU.1 is expressed in B lymphocytes and macrophages and like other Ets-related proteins, binds to consensus sites in DNA through an 85 amino acid Ets domain in the carboxyl terminal region of the protein. The antibody was raised against a bacterially expressed GST-PU.1 fusion protein.

Host Species: Mouse
Clone: G148-74
Isotype: IgG2a
Species Reactivity: Human
Immunogen: PU.1 Fusion Protein
Formula Weight [Chemical]: 40-42kDa

Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen PU.1
Applications Western Blot
Classification Monoclonal
Clone G148-74
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen PU.1 Fusion Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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