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Puma BH3 Domain Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511397

Catalog No. PIPA511397


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Specifications

Specifications

Puma BH3 Domain
Polyclonal
PBS with 0.09% sodium azide
Q96PG8
Bcl-2-binding component 3; p53 up-regulated modulator of apoptosis; JFY-1; BBC3
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
27113
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
BBC3
Liquid
BBC3
KLH conjugated synthetic peptide between 119-154 amino acids from human Puma BH3 Domain
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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