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Pyk2 (pY402) Mouse, Alexa Fluor 647, Clone: L68-1256.272, BD

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BDB560256 50 Tests
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Catalog No. BDB560256 Supplier BD Biosciences Supplier No. 560256
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Description

Mouse Monoclonal Antibody

Proline-rich tyrosine kinase 2 (Pyk2) is a member of the FAK subfamily of tyrosine protein kinases. Pyk2 responds to a wide variety of inflammatory and stress stimuli, such as cytokines, ligation of integrins or antigen receptors, mechanical strain, and cellular depolarization. A common characteristic of most Pyk2 stimuli is an increase in cytosolic free calcium. Pyk2 is involved in signaling pathways that regulate vital cellular functions in hematopoietic, epithelial, neuronal, endothelial, and other cell types. Activation of Pyk2 initiates its autophosphorylation at tyrosine 402 (Y402), followed by Src-mediated phosphorylation of other Pyk2 tyrosine sites, which enhances its activity and leads to
downstream signal transduction through the MAPK and JNK pathways. The L68-1256.272 monoclonal antibody recognizes the phosphorylated Y402 of activated Pyk2.

Host Species: Mouse
Clone: L68-1256.272
Isotype: IgG2b, κ
Species Reactivity: Human
Immunogen: Phosphorylated Human Pyk2 Peptide

Intracellular Staining

TRUSTED_SUSTAINABILITY

Specifications

Antigen Pyk2 (pY402)
Applications Flow Cytometry
Classification Monoclonal
Clone L68-1256.272
Conjugate Alexa Fluor 647
Description Protein tyrosine kinase 2β, FAK2, FADK 2, CAKβ, CADTK, RAFTK
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human Pyk2 Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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