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RAB27 Mouse anti-Human, Unlabeled, Clone: 20.1/RAB27, BD

Catalog No. BDB558532 Shop All BD Biosciences Products
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BDB558532 0.1 mg
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Catalog No. BDB558532 Supplier BD Biosciences Supplier No. 558532
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Description

Mouse Monoclonal Antibody

Members of the Rab family of GTPases are non-transforming, membrane-bound, geranylgeranylated members of the Ras superfamily that are involved in the fusion and trafficking of cellular vesicles. Rab27A is expressed in many human tissues and it regulates the secreation of several types of cellular vesicles, such as melanosomes, insulin granules of pancreatic beta cells, and lytic granules of cytotoxic T lymphocytes. Rab27A is able to regulate such diverse processes by interacting with organelle-specific effector proteins, including melanophilin, granuphilin, and Munc13-4, respectively. Defects in Rab27A function are associated with the human diseases choroideremia and Griscelli syndrome 2 and the ashen mutant mouse. Rab27B is not so widely expressed, yet it is reported to have similar functional capacities as Rab27A. The 20.1 monoclonal antibody recognizes human Rab27A; cross-reactivity with Rab27B is unknown.

Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen RAB27
Applications Western Blot
Classification Monoclonal
Clone 20.1/RAB27
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Rab27A Recombinant Protein
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C
Isotype IgG1 κ
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