RAB3A Rabbit anti-Canine, Hamster, Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1770
PA1-770 detects rab 3A from canine, hamster, human, mouse and rat tissues and cells. PA1-770 has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects an ~21 kDa protein representing rab 3A from Hepa1 cell lysate. PA1-770 immunogen is a synthetic peptide corresponding to residues M(1) A S A T D S R Y G Q K E S S D Q N(18) C of human RAB3A. This sequence is completely conserved between human, mouse, and rat rab 3A. PA1-770 immunizing peptide (Cat. No. PEP-098) is available for use in neutralization and control experiments. Recombit human rab 3A (Cat No. RP-770) protein can be purchased for control experiments in Western blot applications.Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There exist over 40 rab proteins that have been described in mammals and the best studied is rab 3A. Rab 3A is found to be abundant in presynaptic nerve terminals and is also found to be crucial in acrosomal exocytosis in human spermatozoa. Abnormal accumulation of rab 3A in the cytoplasm of Purkinje cells has been reported in the prion protein related Creutzfeldt-Jakob disease.
|Synthetic peptide corresponding to residues M(1) A S A T D S R Y G Q K E S S D Q N(18) C of human RAB3A.|
|Canine, Hamster, Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|antibody with 1mg/mL BSA and 0.05% sodium azide|
|P20336, P63011, P63012|
|Ras-Associated Protein 3A|
|-20° C, Avoid Freeze/Thaw Cycles|
|100759024, 19339, 25531, 484826, 5864|
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