Rab8 Mouse, Unlabeled, Clone: 4, BD

Catalog No.	Quantity
BDB610844	50 μg

Catalog No. BDB610844 Supplier BD Biosciences Supplier No. 610844

Description

Mouse Monoclonal Antibody

The members of the Ras superfamily of GTPases, which now includes more than 50 different proteins, shuttle between the GDP-bound inactive position and the GTP-bound active state. The GTPase activity of the Ras-like proteins is regulated by effectors that promote either the GDP- or the GTP-bound states. GTPases of the Ras superfamily have a role in controlling numerous events such as cell proliferation, nucleocytoplasmic transport, and vesicular traffic. The Rab superfamily of proteins includes more than 30 different members that are involved in the regulation of different steps of vesicular traffic. Subcellular localization and specific cellular function of each Rab appears to be encoded in the unique C terminal part of the proteins, known as the hypervariable region. The 207 amino acid Rab8 protein is closely related to the yeast Sec4p and regulates vesicle transport from the Trans-golgi Network to the basolateral plasma membrane in epithelial cells. In addition, Rab8 interacts with the stress-activated kinase rab8p, a close homologue of the GC Kinase. This interaction was found to be dependent on GTP.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

• Antigen: Rab8
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 4
• Concentration: 250μg/mL
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Human Rab8 aa. 84-205
• Purification Method: Affinity Purified
• Quantity: 50 μg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Canine, Drosophila, Human, Mouse, Rat
• Content And Storage: Store undiluted at -20°C.
• Isotype: IgG2b

For Research Use Only.