Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Rabex-5 Mouse anti-Mouse, Unlabeled, Clone: 27, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612559

 View more versions of this product

Catalog No. BDB612559

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

The Rab proteins are small GTP-binding molecules. They are localized to specific intracellular vesicles and organelles and are important for vesicular trafficking, cycling between an active GTP-bound and inactive GDP-bound form. Rab5 is associated with vesicle trafficking between the early endosomes and plasma membrane. In vitro, Rab5 proteins are removed from membranes by a GDP dissociation inhibitor protein (rabGDI). This leads to the formation of a cytosolic Rab5-rabGDI complex. Rab5 may insert into membranes by a multistep process in which a transient GDP-Rab5 intermediate is formed and converted into GTP- Rab5. Rabaptin-5 interacts with GTP-Rab5, and is recruited to the endosomal fraction in a Rab5/GTP-dependent manner. Removal of Rabaptin-5 from the cytosol substantially impairs GTP and Rab5-dependent endosomal fusion. Rabex-5 forms a complex with Rabaptin-5 and displays GDP/GTP exchange activity on Rab5 that promotes interaction between Rabaptin-5 and Rab5. Rabex-5 is also known as Rin2 based on its 15% identitiy with the RasGTPase-binding protein Rin1. Thus, Rabex-5/Rabaptin-5 complex is critical for Rab5 GDP/GTP exchange and membrane-associated activity.
Specifications

Specifications

Rabex-5
27
Unconjugated
Murine
IgG1
RUO
Primary
Murine
Western Blot
250μg/mL
Affinity Purified
Mouse Rabex-5 aa. 426-481
150μg
Cell Biology
Monoclonal
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only.