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MilliporeSigma™ anti-Rac1 Alexa Fluor 647, Clone: 23A8,

Catalog No. 05389AF647 Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Alexa Fluor 647
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Catalog No. Quantity Conjugate
05-389-AF647 100 μL Alexa Fluor 647
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Catalog No. 05-389-AF647 Supplier MilliporeSigma™ Supplier No. 05389AF647
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Description

Mouse Monoclonal Antibody

Specifically detects Rac1 Clone: 23A8 in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry

Ras-related C3 botulinum toxin substrate 1 (UniProt P63000; also known as Cell migration-inducing gene 5 protein, p21-Rac1, Rac-1, Ras-like protein TC25, TC-25) is encoded by the RAC1 (also known as TC25) gene (ORF MIG5; Gene ID 5879) in human. Rac1, RhoA, and Cdc42 (UniProt P63000, P61586, and P60953, respectively) are among the most studied Rho family of small GTPases that are involved in a wide variety of cellular functions such as cell polarity, vesicular trafficking, and cell cycle by regulating intracellular actin dynamics. In mammals, the Rho family contains 22 members which can be further divided into the Rac subfamily (Rac1, Rac2, Rac3, and RhoG), Cdc42 subfamily (Cdc42, TC10, TCL, Chip, and Wrch-1), RhoA subfamlly (RhoA, RhoB, and RhoC) and other Rho-GTPases (RhoE/Rnd3, RhoH/TTF, Rif, RhoBTB1, RhoBTB2, Miro-1, Miro-2, RhoD, Rnd1, and Rnd2). Akt is reported to negatively regulate mixed-lineage kinase 3 (MLK3) by phosphorylating Rac1 at Ser71.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Rac1
Applications Immunocytochemistry
Classification Monoclonal
Clone 23A8
Conjugate Alexa Fluor 647
Formulation Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Gene Accession No. P63000
Gene Symbols RAC1, TC25, MIG5
Host Species Mouse
Immunogen Recombinant protein containing the full length human Rac.
Purification Method Affinity Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NM_006908
Test Specificity Recognizes Rac1; Strong Rac1 preference with slight Rac2 cross-reactivity.
Target Species Human, Mouse, Rat
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG2b
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For Research Use Only

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