Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ anti-Rad51 (Ab-1), Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC130100UL

Catalog No. PC130100UL


Add to cart

Description

Description

Specifically detects Rad51 Clone: in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunoprecipitation

The bacterial RecA and the yeast RAD51 proteins are involved in homologous recombination and DNA repair. The human RAD51 protein is the homologue of these two proteins. While the modular structure of these proteins is conserved and the homology is very strong with the bacterial protein there are functional differences seen with RAD51 including an ATP hydrolysis rate 1/10 that seen with RecA. Although RAD51 is a nuclear protein and is largely absent from the cytoplasm and nucleoli, the protein lacks a nuclear localization signal and requires other proteins in a complex to be translocated into the nucleus. Treatment of cells with DNA synthesis inducing agents will cause an increase in the levels of RAD51 protein which then undergo a shift in distribution becoming focal in nature. This focal distribution may be blocked by inhibitors of transcription. RAD51 can be shown to interact directly with the chromosomes and during the process of meiosis, its distribution of RAD51 undergoes dynamic change. RAD51 has been shown to interact with a wide variety of different proteins that include the wild-type form of p53, BRCA2, and RAD52, which specifically modulates its activity.
Specifications

Specifications

Rad51
Unconjugated
purified
human Rad51
100μL
−20°C
Polyclonal
Human, Murine, Rat
Immunocytochemistry, Immunoprecipitation
In 150mM NaCl, 100mM Tris-Glycine, pH 7.4
Rabbit
IgG
RUO
Primary
Recognizes the ∽43kDa Rad51 protein in ovarian tissue.
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only