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RAD51 Rabbit anti-Chicken, Human, Mouse, Xenopus laevis, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14985

Catalog No. PIPA14985

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

PA1-4985 detects Rad51 from human, mouse, and chicken samples. PA1-4985 has been successfully used in Western blot, immunoprecipitation, immunocytochemistry and indirect immunofluorescence applications. By Western blot, this antibody detects a 37 kDa band representing Rad51 from Hela cells. GFP-tagging of Rad51 protein at either N- or C- terminus inactivates the function of Rad51 and therefore it cannot be used for the study of foci formation instead of the antibody. The PA1-4985 immunogen is full-length recombit Rap51 protein.

RAD51 plays a critical role in homologous strand exchange, a key step in DNA repair through homologous recobination. It binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. RAD51 catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. It binds to a single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Mutations in the gene can results in breast cancer, mirror movements 2 and fanconi anemia.
Specifications

Specifications

RAD51
Polyclonal
whole serum with 0.09% sodium azide
P37383, Q06609, Q08297, Q91918
BRCC5, HRAD51, HsRad51, HsT16930, RAD51A, RECA
Rabbit
IgG
RUO
Antibody
Polyclonal
Chicken, Human, Mouse, Xenopus laevis
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
RAD51
Liquid
RAD51, rad51.L
Purified full-length recombit Rap51 protein.
50 μL
4° C
Primary
19361, 396086, 397726, 5888
Documents
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