RAD51 Rabbit anti-Chicken, Human, Mouse, Xenopus laevis, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14985
PA1-4985 detects Rad51 from human, mouse, and chicken samples. PA1-4985 has been successfully used in Western blot, immunoprecipitation, immunocytochemistry and indirect immunofluorescence applications. By Western blot, this antibody detects a 37 kDa band representing Rad51 from Hela cells. GFP-tagging of Rad51 protein at either N- or C- terminus inactivates the function of Rad51 and therefore it cannot be used for the study of foci formation instead of the antibody. The PA1-4985 immunogen is full-length recombit Rap51 protein.RAD51 plays a critical role in homologous strand exchange, a key step in DNA repair through homologous recobination. It binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. RAD51 catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. It binds to a single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Mutations in the gene can results in breast cancer, mirror movements 2 and fanconi anemia.
|whole serum with 0.09% sodium azide|
|P37383, Q06609, Q08297, Q91918|
|BRCC5, HRAD51, HsRad51, HsT16930, RAD51A, RECA|
|Chicken, Human, Mouse, Xenopus laevis|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|Purified full-length recombit Rap51 protein.|
|19361, 396086, 397726, 5888|
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