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RANKL/TRANCE Rat anti-Mouse, PE, Clone: IK22-5, BD

Catalog No. BDB560295 Shop All BD Biosciences Products
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BDB560295 0.1 mg
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Catalog No. BDB560295 Supplier BD Biosciences Supplier No. 560295

Description

Rat Monoclonal Antibody

TRANCE/RANKL/OPGL/ODF is a recently identified member of the tumor necrosis factor family. TRANCE (TNF-Related Activation-Induced Cytokine Receptor) or RANKL (Receptor Activator of NF-kB Ligand) has been implicated in interactions between T cells and dendritic cells. TRANCE/RANKL binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. TRANCE/RANKL is also important in T- and B-cell maturation. As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast Differentiation Factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis. It is expressed abundantly by mouse activated T cells, not B cells. It is also expressed on osteoclasts.

Host Species: Rat
Clone: IK22-5
Isotype: IgG2a κ
Species Reactivity: Mouse
Immunogen: Mouse recombinant RANKL

Flow Cytometry

TRUSTED_SUSTAINABILITY

Specifications

Antigen RANKL/TRANCE
Applications Flow Cytometry
Classification Monoclonal
Clone IK22-5
Concentration 0.2mg/mL
Conjugate PE
Description TRANCE, TRANCEODF, OPGL, sOdf, CD254, OPTB2, hRANKL2
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen Mouse recombinant RANKL
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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