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RANTES Mouse anti-Human, Alexa Fluor 647, Clone: 2D5, BD

Catalog No. BDB564753 Shop All BD Biosciences Products
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BDB564753 50 Tests
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Catalog No. BDB564753 Supplier BD Biosciences Supplier No. 564753

Description

Mouse Monoclonal Antibody

The 2D5 monoclonal antibody specifically binds to human Regulated upon Activation, Normal T cells Expressed and Secreted (RANTES). RANTES belongs to the C-C family of chemokines and is also known as CCL5. RANTES is produced by activated macrophages, CD8+ T cells, platelets, fibroblasts, epithelial cells and some tumor cells. RANTES is a chemoattractant and response modifier for a variety of cells including memory T cells, NK cells, dendritic cells, monocytes, eosinophils, basophils, and mast cells. RANTES binds to and transduces intracellular signals through several cell surface chemokine receptors including CCR1, CCR3, CCR4, and CCR5. RANTES can reportedly inhibit the interaction between certain HIV viruses and CCR5 and thus suppress viral infection in vitro.

TRUSTED_SUSTAINABILITY

Specifications

Antigen RANTES
Applications Flow Cytometry
Classification Monoclonal
Clone 2D5
Conjugate Alexa Fluor 647
Description CCL5; chemokine (C-C motif) ligand 5; EoCP; SCYA5; SIS-delta; SISd; TCP228
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Recombinant Human RANTES Protein
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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