CCL5 (RANTES), PE, clone: 21445, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA523619

Catalog No. PIMA523619

Description

This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.

In direct ELISAs and Western blots, this antibody does not cross-react with other chemokines, including recombinant human CCL2, 3, 4 recombinant mouse (rm) CCL3, and rmCCL4.

Specifications

• Antigen: CCL5 (RANTES)
• Classification: Monoclonal
• Conjugate: PE
• Gene: CCL5
• Gene Alias: C-C motif chemokine 5, SIS-delta, T-cell specific protein p288, T-cell-specific protein RANTES, beta-chemokine RANTES, eoCP, eosinophil chemotactic cytokine, small inducible cytokine A5, t cell-specific protein P228, D17S136E, MGC17164, SCYA5, SISd, TCP228
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 6352
• Content And Storage: Store at 4°C, store in the dark, do not freeze
• Form: Liquid

• Applications: Flow Cytometry
• Clone: 21445
• Formulation: Buffered saline solution with BSA and 0.1% sodium azide
• Gene Accession No.: P13501
• Gene Symbols: CCL5
• Immunogen: E. coli-derived recombinant human CCL5/RANTES
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1