Rb2 Mouse, Unlabeled, Clone: 10, BD

Catalog No.	Quantity
BDB610262	150 μg
BDB610261	50 μg

Catalog No. BDB610262 Supplier BD Biosciences Supplier No. 610262

Description

Mouse Monoclonal Antibody

The pRb2 protein shows a high degree of identity with pRb and the related p107 protein. Both pRb and p107 bind to the adenovirus E1A, SV40 large T antigen, and papillomavirus E7 viral proteins. This binding initiates the release of transcription factors which are required for the expression of cell cycle-regulated genes. pRb, pRb2, and p107 interact with a conserved motif in these three viral proteins. In the E1A protein, this area is known as transforming domain 2, which is required for growth activation. The E1A-binding domain in pRb and p107 is a conserved motif known as the “pocket region” which consists of conserved A and B regions separated by non-conserved spacers of different sizes in pRb and p107. It is the pocket regions of pRb and p107 that associate with the E2F transcription factor. pRb2 also contains the conserved pocket region suggesting that it has functional similarities to pRb and p107.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: Rb2
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 10
• Concentration: 250μg/mL
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Host Species: Mouse
• Immunogen: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Quantity: 150 μg
• Regulatory Status: RUO
• Research Discipline: Cell Biology
• Primary or Secondary: Primary
• Target Species: Chicken, Drosophila, Human, Mouse, Rat
• Content And Storage: Store undiluted at -20°C.
• Isotype: IgG2a

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.