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RECK Mouse anti-Human, Unlabeled, Clone: 28, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611512

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Catalog No. BDB611512

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.



Reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) was identified in an assay that characterized genes inducing flat morphology in a v-Ki-ras-transformed NIH 3T3 cell line. RECK is a glycoprotein that contains two hydrophobic regions, the C-terminal is involved in GPI-anchoring, five repeats of a putative six-cysteine knot motif, two EGF-like regions (E), and three serine-protease inhibitor-like domains (S), one of which (635-654) is a Kazal motif (C-X7-C-X6-Y-X3-C-X2.3-C). In normal human tissues, RECK is expressed ubiquitously, however it is not detectable in many malignant cell lines. Downregulation of RECK transcription in malignant cells may involve ras-dependent negative regulation of the RECK gene via an upstream promoter region that contains an Sp1 motif. Transfection of tumor cell lines with RECK can inhibit tumor invasion and metastatic activity independent of chemotactic activity. This inhibitory effect may be a result RECK-induced inhibition of MMP-9 secretion or protease activity. Thus, RECK may be an important inhibitor of matrix metalloproteinase activity and suppression of RECK may be required for both tumor cell invasion and metastasis.

Host Species: Mouse
Clone: 28
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human RECK aa. 559-760
Formula Weight [Chemical]: 110kDa

Immunofluorescence, Western Blotting



Immunofluorescence, Immunohistochemistry, Western Blot
Affinity Purified
Human RECK aa. 559-760
Cell Biology
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