MilliporeSigma™ anti-RENT1, Polyclonal

Goat Polyclonal Antibody

Supplier:  MilliporeSigma™ DR1015100UG

Catalog No. DR1015100UG

Description

Specifically detects RENT1 Clone: in Human samples, and it is validated for Immuno Blotting

Eukaryotes have the ability to recognize and degrade transcripts that harbor premature signals for translational termination. Nonsense and frameshift mutations that result in these premature termination codons play a role in many genetic diseases and some cancers. Nonsense-mediated nRNA decay (NMD) is mediated by several factors including rent1/hUpf1, rent2/hUpf2, and hUpf3. When assembled, these proteins form the surveillence complex. Disruption of the mouseRent1 gene has been reported to completely disrupt NMD and result in embryos that re-absorb shortly after implantation.

Specifications

• Antigen: RENT1
• Classification: Polyclonal
• Formulation: In Tris/citrate phosphate buffer, pH 7.0-8.0.
• Immunogen: a synthetic peptide corresponding to amino acids at the C-terminus of human RENT1
• Regulatory Status: RUO
• Test Specificity: Recognizes the ∽140kDa RENT1 protein in HeLa cells.
• Content And Storage: 2°C to 8°C
• Isotype: IgG

• Applications: Immunoblot
• Conjugate: Unconjugated
• Host Species: Goat
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only