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MilliporeSigma™ anti-Retinal Dehydrogenase 1/ALDH1A1 Clone: 8D7.1,

Catalog No. MABN838MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABN838MI 100 μg Unconjugated
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Catalog No. MABN838MI Supplier MilliporeSigma™ Supplier No. MABN838
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Description

Mouse Monoclonal Antibody

Specifically detects Retinal Dehydrogenase 1/ALDH1A1 Clone: 8D7.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Retinal dehydrogenase 1 (EC 1.2.1.36; UniProt P00352; also known as Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase family 1 member A1, ALDH-E1, ALHDII, RALDH 1, RalDH1) is encoded by the ALDH1A1 (also known as ALDC, ALDH1, PUMB1) gene (Gene ID 216) in human. ALDH1A1, ALDH1A2, and ALDH1A3 constitute the ALDH1A subfamily of aldehyde dehydrogenases that catalyze the oxidation of all-trans retinal and 9-cis retinal to all-trans retinoic acid and 9-cis retinoic acid, respectively. In addition to its role in detoxifing 4-hydroxy-2-nonenal (4-HNE) in the lens and cornea, ALDH1A1 is also involved in many other biological processes, including stem cell maintenance, UV-radiation resistance, melanogenesis, and spermatogenesis, by catalyzing the conversion of specific aldehydes to their corresponding carboxylic acids.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Retinal Dehydrogenase 1/ALDH1A1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 8D7.1
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG1k antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P00352
Gene Symbols ALDH1A1, ALDC, ALDH1, PUMB1
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to the N-terminal of human Retinal Dehydrogenase 1/ALDH1A1.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_000680
Target Species Human
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG1 κ
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For Research Use Only

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