MilliporeSigma™ anti-Ric-8B/Synembryn-B, Polyclonal

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABS1614

Catalog No. ABS1614MI

Description

Specifically detects Ric-8B/Synembryn-B Clone: in Human, Mouse, Rabbit samples, and it is validated for Immunoprecipitation, Western Blotting

Synembryn-B (UniProt Q80XE1; also known as Protein Ric-8B, Resistance to inhibitors of cholinesterase 8B) is encoded by the Ric8b (also known as BC051080) gene (Gene ID 237422) in murine species. Ric-8A and Ric-8B stimulate nucleotide exchange of all Gα subunit classes by stabilizing the Gα nucleotide-free transition state. Ric-8A acts upon Gαi/q/13, while Ric-8B targets Gαs/olf. In addition to their function as guanine nucleotide exchange factors (GEFs), Ric proteins also act as molecular chaperones that directly participate in the posttranslational folding of nascent Gα subunits to promote G-protein biosynthesis and membrane association. Ric-8 knockdown reduces Gα steady-state abundances and overexpression of Ric-8 proteins enhances cellular Gα levels. In Ric-8A– or Ric-8B–delicient ES cells, newly produced Gα subunits are defective in the initial association with an internal membrane, resulting in a ∼10-fold faster turned over rate than in WT cells.

Specifications

• Antigen: Ric-8B/Synembryn-B
• Classification: Polyclonal
• Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
• Gene Symbols: Ric8b
• Immunogen: Recombinant protein corresponding to mouse Ric-8B/Synembryn-B.
• Quantity: 100 μL
• Research Discipline: Signaling
• Gene ID (Entrez): NP_898995
• Target Species: Human, Mouse, Rabbit
• Form: Serum

• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Gene Accession No.: Q80XE1
• Host Species: Rabbit
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Expected to react with all murine and human spliced isoforms (UniProt Q80XE1, Q9NVN3).
• Content And Storage: −20°C for one year

For Research Use Only