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MilliporeSigma™ anti-Ric-8B/Synembryn-B, Polyclonal

Catalog No. ABS1614MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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ABS1614MI 100 μL Unconjugated
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Catalog No. ABS1614MI Supplier MilliporeSigma™ Supplier No. ABS1614
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Description

Rabbit Polyclonal Antibody

Specifically detects Ric-8B/Synembryn-B Clone: in Human, Mouse, Rabbit samples, and it is validated for Immunoprecipitation, Western Blotting

Synembryn-B (UniProt Q80XE1; also known as Protein Ric-8B, Resistance to inhibitors of cholinesterase 8B) is encoded by the Ric8b (also known as BC051080) gene (Gene ID 237422) in murine species. Ric-8A and Ric-8B stimulate nucleotide exchange of all Gα subunit classes by stabilizing the Gα nucleotide-free transition state. Ric-8A acts upon Gαi/q/13, while Ric-8B targets Gαs/olf. In addition to their function as guanine nucleotide exchange factors (GEFs), Ric proteins also act as molecular chaperones that directly participate in the posttranslational folding of nascent Gα subunits to promote G-protein biosynthesis and membrane association. Ric-8 knockdown reduces Gα steady-state abundances and overexpression of Ric-8 proteins enhances cellular Gα levels. In Ric-8A– or Ric-8B–delicient ES cells, newly produced Gα subunits are defective in the initial association with an internal membrane, resulting in a ∼10-fold faster turned over rate than in WT cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ric-8B/Synembryn-B
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation Rabbit polyclonal serum with 0.05% sodium azide.
Gene Accession No. Q80XE1
Gene Symbols Ric8b
Host Species Rabbit
Immunogen Recombinant protein corresponding to mouse Ric-8B/Synembryn-B.
Purification Method Unpurified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_898995
Test Specificity Expected to react with all murine and human spliced isoforms (UniProt Q80XE1, Q9NVN3).
Target Species Human, Mouse, Rabbit
Content And Storage −20°C for one year
Form Serum
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For Research Use Only

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