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RIM3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520475

Catalog No. PIPA520475


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-20475 can be used with blocking peptide PEP-0595.

Rab3-interacting molecules (RIMs) are synaptic proteins are synaptic proteins necessary for neural transmission and plasticity. While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis. Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity.
Specifications

Specifications

Rim3
Polyclonal
Unconjugated
RIMS3
Liquid
RIMS3
A 17 amino acid peptide from near the amino terminus of human Rim3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9UJD0, Q80U57
RP4-739H11.2, NIM3, RIM3; RIM 3; RIM3 gamma; Rab-3 interacting molecule 3; rab-3-interacting molecule 3; regulating synaptic membrane exocytosis protein 3
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
242662, 9783
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