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MilliporeSigma™ anti-RNA polymerase II Alexa Fluor 488, Clone: CTD4H8,

Catalog No. 05623AF488 Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Alexa Fluor 488
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Catalog No. Quantity Conjugate
05-623-AF488 100 μL Alexa Fluor 488
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Catalog No. 05-623-AF488 Supplier MilliporeSigma™ Supplier No. 05623AF488
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Description

Mouse Monoclonal Antibody

Specifically detects RNA polymerase II Clone: CTD4H8 in Human, Mouse samples, and it is validated for Immunocytochemistry

DNA-directed RNA polymerase II subunit RPB1 (EC 2.7.7.6; EC 2.7.7.48; UniProt P24928; also known as DNA-directed RNA polymerase II subunit A, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase III largest subunit, hRPB220, hsRPB1, RNA polymerase II subunit B1, RPBh1, RpIILS) is encoded by the POLR2A (also known as POLR2, POLRA, RPB1, RPO2, RPOL2) gene (Gene ID 5430) in human. RNA polymerase II (Pol II) is a 550kDa, multi-subunit enzyme responsible for the transcription of protein-coding genes. Transcription initiation requires recruitment of the complete transcription machinery to a promoter via solicitation by activators and chromatin remodeling factors. Pol II can coordinate 10 to 14 subunits. This complex interacts with the promoter regions of genes and a variety of elements and transcription factors. The DNA binding domain of the polymerase is a groove where TFIIB orients the DNA for unwinding and transcription.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNA polymerase II
Applications Immunocytochemistry
Classification Monoclonal
Clone CTD4H8
Conjugate Alexa Fluor 488
Formulation Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Gene Accession No. P24928
Gene Symbols POLR2A, POLR2
Host Species Mouse
Immunogen KLH-conjugated, synthetic peptide containing 10 repeats of YSPT[pS]PS corresponding to the carboxyl-terminal domain of RNA polymerase II.
Purification Method Protein G purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Epigenetics, Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_000928.1
Test Specificity This antibody recognizes Phospho- and non-phospho-RNA polymerase II.
Target Species Human, Mouse
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG1
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For Research Use Only

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