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MilliporeSigma™ anti-RNA polymerase II Alexa Fluor 488, Clone: CTD4H8,

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ 05623AF488

Catalog No. 05-623-AF488

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Specifically detects RNA polymerase II Clone: CTD4H8 in Human, Mouse samples, and it is validated for Immunocytochemistry

DNA-directed RNA polymerase II subunit RPB1 (EC; EC; UniProt P24928; also known as DNA-directed RNA polymerase II subunit A, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase III largest subunit, hRPB220, hsRPB1, RNA polymerase II subunit B1, RPBh1, RpIILS) is encoded by the POLR2A (also known as POLR2, POLRA, RPB1, RPO2, RPOL2) gene (Gene ID 5430) in human. RNA polymerase II (Pol II) is a 550kDa, multi-subunit enzyme responsible for the transcription of protein-coding genes. Transcription initiation requires recruitment of the complete transcription machinery to a promoter via solicitation by activators and chromatin remodeling factors. Pol II can coordinate 10 to 14 subunits. This complex interacts with the promoter regions of genes and a variety of elements and transcription factors. The DNA binding domain of the polymerase is a groove where TFIIB orients the DNA for unwinding and transcription.


RNA polymerase II
Purified mouse antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Epigenetics, Nuclear Function
Human, Murine
Alexa Fluor 488
KLH-conjugated, synthetic peptide containing 10 repeats of YSPT[pS]PS corresponding to the carboxyl-terminal domain of RNA polymerase II.
Protein G purified
2°C to 8°C for one year from date of shipment
This antibody recognizes Phospho- and non-phospho-RNA polymerase II.
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