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ROCK-II Mouse, Unlabeled, Clone: 21, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610623

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Catalog No. BDB610623


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Description

Description

Activity of the GTP-binding proteins is regulated by GAPs, that accelerate binding, and GTPases, that enhance the rate of GTP hydrolysis (Ras, Rho, cdc42Hs, and Rac). The isoforms of Rho, a small GTP-binding protein, regulate cellular processes such as the formation of the stress fibers, lamelipodia, and filopodia. ROKα (RhoA-binding kinase) is a Ser/Thr protein kinase that interects with the GTP-binding form of RhoA. Like RhoA, ROKα localizes at the cellular margins and colocalizes with acti filaments. The ROKα gene encodes a protein of 1302 amino acids with homology to the human myotonic kinase. Although ROKα binds to GTP-RhoA, it is not yet clear whether this interaction induces the kinase activity of ROKα.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

ROCK-II
21
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
ROKα
Affinity Purified
Rat ROKα aa. 567-718
50μg
Cell Biology
Primary
Canine, Human, Murine, Rat
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