ROCK-II Mouse, Unlabeled, Clone: 21, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610623
Activity of the GTP-binding proteins is regulated by GAPs, that accelerate binding, and GTPases, that enhance the rate of GTP hydrolysis (Ras, Rho, cdc42Hs, and Rac). The isoforms of Rho, a small GTP-binding protein, regulate cellular processes such as the formation of the stress fibers, lamelipodia, and filopodia. ROKα (RhoA-binding kinase) is a Ser/Thr protein kinase that interects with the GTP-binding form of RhoA. Like RhoA, ROKα localizes at the cellular margins and colocalizes with acti filaments. The ROKα gene encodes a protein of 1302 amino acids with homology to the human myotonic kinase. Although ROKα binds to GTP-RhoA, it is not yet clear whether this interaction induces the kinase activity of ROKα.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Rat ROKα aa. 567-718|
|Canine, Human, Murine, Rat|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok
For Research Use Only.