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RONα Mouse, Unlabeled, Clone: 29, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610745

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Catalog No. BDB610745

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

RON (Recepteur d ft. Origine Nantaise) is a tyrosine kinase receptor for MSP (Macrophage Stimulating Protein) that belongs to the hepatocyte growth factor receptor family. RON is synthesized as a single chain glycosylated polypeptide of 1400 amino acids that is cleaved upon maturation into a 150kDa β-subunit with the kinase activity and a 40kDa α-chain. Both chains are linked by disulfide bonds and the proper arrangement of the α and β heterodimer is necessary for biological activity of RON. MSP induces the tyrosine kinase activity of RON, triggering a cascade of intracellular signaling that leads to DNA synthesis. However, RON activation in mouse erythroleukemia cells results in apoptosis. The replacement of autophosphorylation sites Y1330 and Y1337 abolishes both the mitogenic and apoptotic effects of MSP. Therefore, autophosphorylation at Y1330 and Y1337 is required for RON's biological activity. PLCγ, Shc, Grb2, p61, and p65 associate with RON. Although widely expressed, RON is particularly abundant in epithelial tissues, lung, brain, adrenal glands, gastrointestinal tract, kidney and testis.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

RONα
29
Unconjugated
Murine
IgG2b
RUO
Primary
Canine, Frog, Human, Murine, Rat
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human RONα aa. 40-224
150μg
Cell Biology
Monoclonal
Documents
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