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RONα Mouse, Unlabeled, Clone: 29, BD

Catalog No. BDB610745 Shop All BD Biosciences Products
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BDB610745 150 μg
BDB610744 50 μg
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Catalog No. BDB610745 Supplier BD Biosciences Supplier No. 610745

Description

Mouse Monoclonal Antibody

RON (Recepteur d′ Origine Nantaise) is a tyrosine kinase receptor for MSP (Macrophage Stimulating Protein) that belongs to the hepatocyte growth factor receptor family. RON is synthesized as a single chain glycosylated polypeptide of 1400 amino acids that is cleaved upon maturation into a 150kDa β-subunit with the kinase activity and a 40kDa α-chain. Both chains are linked by disulfide bonds and the proper arrangement of the α and β heterodimer is necessary for biological activity of RON. MSP induces the tyrosine kinase activity of RON, triggering a cascade of intracellular signaling that leads to DNA synthesis. However, RON activation in mouse erythroleukemia cells results in apoptosis. The replacement of autophosphorylation sites Y1330 and Y1337 abolishes both the mitogenic and apoptotic effects of MSP. Therefore, autophosphorylation at Y1330 and Y1337 is required for RON's biological activity. PLCγ, Shc, Grb2, p61, and p65 associate with RON. Although widely expressed, RON is particularly abundant in epithelial tissues, lung, brain, adrenal glands, gastrointestinal tract, kidney and testis.

Immunofluorescence, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen RONα
Applications Immunofluorescence, Western Blot
Classification Monoclonal
Clone 29
Concentration 250μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Human RONα aa. 40-224
Purification Method Affinity Purified
Quantity 150 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Frog, Human, Mouse, Rat
Isotype IgG2b
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For Research Use Only.

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