RORgammat Mouse anti-Human, Alexa Fluor 488, Clone: Q21-559, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 563621

Catalog No. BDB563621

Description

The Q21-559 monoclonal antibody recognizes ROR gamma t (RORγt), an isoform of ROR gamma (RORγ). RORγt is a DNA-binding transcription factor that is encoded by the RORC (RAR-related orphan receptor C) gene. It belongs to the ROR/RZR orphan nuclear receptor family. Two protein isoforms are produced from the RORC gene by alternative splicing: ROR γγt is highly restricted to the thymus where it is expressed exclusively in immature CD4+CD8+ thymocytes and in peripheral Th17 and LTi cells. ROR γt reportedly functions as an essential transcription factor for the development of secondary lymphoid tissues. It also plays an important regulatory role in thymopoiesis and effector T cell differentiation, especially for Th17 cells.

Specifications

• Antigen: RORgammat
• Clone: Q21-559
• Description: RORgt; ROR gamma t; RORC; NR1F3; RORG; RZRG; TOR; RZR-GAMMA
• Format: Affinity Purified
• Immunogen: Human RORgamma t Recombinant Protein
• Quantity: 50 Tests
• Storage Requirements: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry
• Conjugate: Alexa Fluor 488
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Host Species: Murine
• Isotype: IgG_2b, κ
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human