ROR1 Mouse anti-Human, Unlabeled, Clone: 4A5, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564464
The 4A5 monoclonal antibody binds to the glycosylated type I membrane protein ROR1 (Receptor-tyrosine-kinase-like Orphan Receptor 1). The ROR1 and ROR2 related proteins are highly conserved evolutionarily and are primarily expressed during embryogenesis. ROR1 is not expressed on normal peripheral blood lymphocytes. ROR1 is similar to tropomyosin receptor kinase (Trk family) neurotropic receptors and shares a cysteine-rich domain with Frizzled receptors for Wnt-family signaling proteins, which are involved in the regulation of embryogenesis and carcinogenesis. Furthermore, there is mounting evidence that aberrant ROR1 expression contributes to human malignancy.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Store undiluted at 4°C|
|Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1|
|Human ROR1 cDNA|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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