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ROR1 Mouse anti-Human, PE, Clone: 4A5, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564474

Catalog No. BDB564474


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Description

Description

The 4A5 monoclonal antibody binds to the glycosylated type I membrane protein ROR1 (Receptor-tyrosine-kinase-like Orphan Receptor 1). The ROR1 and ROR2 related proteins are highly conserved evolutionarily and are primarily expressed during embryogenesis. ROR1 is not expressed on normal peripheral blood lymphocytes. ROR1 is similar to tropomyosin receptor kinase (Trk family) neurotropic receptors and shares a cysteine-rich domain with Frizzled receptors for Wnt-family signaling proteins, which are involved in the regulation of embryogenesis and carcinogenesis. Furthermore, there is mounting evidence that aberrant ROR1 expression contributes to human malignancy.

Specifications

Specifications

ROR1
4A5
Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1
Affinity Purified
Human ROR1 cDNA
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Human
Flow Cytometry
PE
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG2b, κ
50 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Documents
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