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DDIT4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520496

Catalog No. PIPA520496


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Description

Description

A suggested positive control is 293 cell lysate. PA5-20496 can be used with blocking peptide PEP-0616.

RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
Specifications

Specifications

DDIT4
Polyclonal
Unconjugated
DDIT4
Liquid
DDIT4
A 14 amino acid peptide from near the amino terminus of human RTP801.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9NX09, Q9D3F7, Q8VHZ9
Dig2, REDD-1, REDD1, RP11-442H21.1, RTP801; DNA damage-inducible transcript 4 protein; HIF-1 responsive RTP801 (RTP801); HIF-1 responsive protein RTP801; protein regulated in development and DNA damage response 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
140942, 54541, 74747
Documents
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