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S6 (pS244) Mouse, Alexa Fluor 647, Clone: N5-676, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 560465

Catalog No. BDB560465


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Description

Description

Ribosomal protein S6 (∽29kDa calculated and ∽32kDa observed molecular weights) is a component of the 40S ribosomal subunit and belongs to the S6E family of ribosomal proteins. The S6 ribosomal protein plays a role in regulating the translation of RNAs and thus controlling the growth and proliferation of cells. S6 ribosomal protein phosphorylation, especially at multiple C-terminal serine residues S235, S236, S240, and S244, activates S6. The activated S6 ribosomal protein in turn upregulates the ribosomal translation of RNA species coding for other ribosomal proteins, peptide elongation factors and other proteins involved in cell cycle entry and progression. These phosphorylations are mediated by various kinases (e.g., p70S6K and PKCD) activated through cellular responses to growth factors, cytokines, tumor promoting agents, and mitogens. The S6 ribosomal protein can be dephosphorylated in growth-arrested cells. The N5-676 monoclonal antibody specifically detects the S6 ribosomal protein phosphorylated at S244.

Host Species: Mouse
Clone: N5-676
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human ribosomal protein S6 Peptide

Intracellular Staining

Specifications

Specifications

S6 (pS244)
N5-676
40S ribosomal protein S6; Phosphoprotein NP33; RPS6; RS6
Affinity Purified
Phosphorylated Human ribosomal protein S6 Peptide
50 Tests
Cell Biology
Primary
Human, Murine, Rat
Flow Cytometry
Alexa Fluor 647
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Mouse
IgG1, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
SDS
Documents
Product Certifications
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