S6 (pS244) Mouse, Alexa Fluor 647, Clone: N5-676, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 560465
Ribosomal protein S6 (∽29kDa calculated and ∽32kDa observed molecular weights) is a component of the 40S ribosomal subunit and belongs to the S6E family of ribosomal proteins. The S6 ribosomal protein plays a role in regulating the translation of RNAs and thus controlling the growth and proliferation of cells. S6 ribosomal protein phosphorylation, especially at multiple C-terminal serine residues S235, S236, S240, and S244, activates S6. The activated S6 ribosomal protein in turn upregulates the ribosomal translation of RNA species coding for other ribosomal proteins, peptide elongation factors and other proteins involved in cell cycle entry and progression. These phosphorylations are mediated by various kinases (e.g., p70S6K and PKCD) activated through cellular responses to growth factors, cytokines, tumor promoting agents, and mitogens. The S6 ribosomal protein can be dephosphorylated in growth-arrested cells. The N5-676 monoclonal antibody specifically detects the S6 ribosomal protein phosphorylated at S244.
Host Species: Mouse
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Phosphorylated Human ribosomal protein S6 Peptide
|40S ribosomal protein S6; Phosphoprotein NP33; RPS6; RS6|
|Phosphorylated Human ribosomal protein S6 Peptide|
|Human, Murine, Rat|
|Alexa Fluor 647|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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