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MilliporeSigma™ anti-SAMHD1 Clone: I19-18,

Catalog No. MABF933MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABF933MI 100 μg Unconjugated
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Catalog No. MABF933MI Supplier MilliporeSigma™ Supplier No. MABF933
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Description

Mouse Monoclonal Antibody

Specifically detects SAMHD1 Clone: I19-18 in Human samples, and it is validated for Flow Cytometry, Immunocytochemistry, Western Blotting

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (UniProt Q9Y3Z3; also known as DCIP, Dendritic cell-derived IFNG-induced protein, dNTPase, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1) is encoded by the SAMHD1 (also known as CHBL2, HDDC1, MOP5, SBBI88) gene (Gene ID 25939) in human. The sterile alpha motif domain and histidine-aspartate domain-containing protein 1 (SAMHD1) is a dGTP/GTP-activated deoxynucleotide (dNTP) triphosphohydrolase regulated by Cyclin A2/CDK1-dependent phosphorylation and is involved in balancing cellular dNTP pools. SAMHD1 was originally identified as a disease gene associated with the rare infantile encephalopathy Aicardi-Goutières syndrome. SAMHD1 was later shown to restrict HIV-1 replication in non-dividing myeloid-lineage cells and resting T cells by reducing the cellular dNTP concentration. Simian immunodeficiency viruses (SIVs) are found to use their Vpx/Vpr accessory proteins to engage and modify host Cullin-RING-type E3 ubiquitin ligases substrate recognition to target SAMHD1 for poly-ubiquitylation and subsequent proteasomal degradation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SAMHD1
Applications Flow Cytometry, Immunocytochemistry, Western Blot
Classification Monoclonal
Clone I19-18
Conjugate Unconjugated
Formulation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q9Y3Z3
Gene Symbols SAMHD1, CHBL2, HDDC1, MOP5, SBBI88
Host Species Mouse
Immunogen GST-tagged recombinant full-length human SAMHD1.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation, Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_056289
Target Species Human
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG1 κ
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For Research Use Only

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