MilliporeSigma™ anti-SAPK/JNK, Polyclonal

Catalog No.	Quantity	Conjugate
55-930-4200UL	200 μL	Unconjugated

Catalog No. 55-930-4200UL Supplier MilliporeSigma™ Supplier No. 559304200UL

Description

Rabbit Polyclonal Antibody

Specifically detects SAPK/JNK Clone: in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry

The Stress-activated protein kinases (SAPK), also referred to as Jun N-terminal kinases (JNK), function in a protein kinase cascade transducing cellular stress signals. SAPK/JNKs are activated by a highly diverse group of extracellular signals, including UV light, inflammatory cytokines and a wide variety of cellular stresses. Activation occurs via phosphorylation at Thr¹⁸³ and Tyr¹⁸⁵ by the dual specificity enzyme SEK/MKK4 and as yet unidentified kinases. Since dual phosphorylation of SAPK/JNK at Thr¹⁸³/Tyr¹⁸⁵ is essential for kinase activity, phosphorylation at this site is an excellent marker of SAPK/JNK activity. Activated SAPK in turn phosphorylates and activates several transcription factors, including c-jun at Ser^63/73 and ATF-2 at Ser^69/71.

Specifications

• Antigen: SAPK/JNK
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: In 150mM NaCl, 10mM HEPES, 50% glycerol, 0.01% BSA, pH 7.5.
• Host Species: Rabbit
• Immunogen: a full-length, recombinant, human p54 SAPK/JNK2 fusion protein
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes the ∽54kDa SAPK/JNK protein in uv-treated HEK293 cells.
• Target Species: Human, Mouse, Rat
• Content And Storage: −20°C
• Form: Purified
• Isotype: IgG

For Research Use Only