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SATB1 Mouse, Unlabeled, Clone: 14, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611182

Catalog No. BDB611182


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Description

Description

Packaging of fully functional eukaryotic chromosomal DNA within the nucleus requires a highly ordered organizational process. Central to this is the formation of nucleosomes, which consist of octameric histone cores with defined segments of chromatin wound around them, and the interaction of nucleosomes with nuclear matrix components. Such specific genomic DNA segments that interact with the nuclear matrix are called scaffold or matrix attachment regions (SARs or MARs). SATB1 (Special AT-rich sequence-Binding protein 1), expressed
predominantly in the thymus, is a homeodomain MAR binding protein. It recognizes ATC sequences that consist of stretches of A's, T's, and C's on one DNA strand. These sequences tend to unwind by extensive base-unpairing in response to negative superhelical strain. SATB1 exclusively binds double stranded DNA in the minor groove with minimal base contact and it has a low affinity for supercoiled DNA. In addition, SATB1 is thought to act as a transcriptional repressor. SATB1 is a MAR binding protein that binds to the base of chromatin loops and may be essential to T cell-specific gene regulation.

Host Species: Mouse
Clone: 14
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human SATB1 aa. 550-667
Formula Weight [Chemical]: 106kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

SATB1
14
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
SATB homeobox 1; Special AT-rich sequence-binding protein 1
Affinity Purified
Human SATB1 aa. 550-667
50μg
Cell Biology
Primary
Human, Murine, Rat
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