SCF Mouse anti-Human, Clone: 13302, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523705
This antibody detects Recombinant human SCF in Western blots. In sandwich ELISAs, no significant cross-reactivity or interference was observed with 36 other cytokines. Reconstitute at 0.5 mg/mL in sterile PBS.Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
|PBS with 5% trehalose and No Preservative|
|FPH2, KL-1, Kitl, MGF, SCF, SF, SHEP7, kit-ligand, c-Kit ligand, familial progressive hyperpigmentation 2, kit ligand, mast cell growth factor, steel factor, stem cell factor|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|E. coli-derived recombit human SCF Glu26-Ala189|
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