MilliporeSigma™ anti-Sclerostin Clone: 7B6.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABS445

Catalog No. MABS445MI

Description

Specifically detects Sclerostin Clone: 7B6.1 in Human, Rat samples, and it is validated for Immunohistochemistry, Western Blotting

Sclerostin (UniProt Q9BQB4) is encoded by the SOST (also known as CDD, SOST1, VBCH) gene (ORP UNQ2976/PRO7455/PRO7476; Gene ID 50964) in human. Sclerostin is a glycoprotein expressed in osteocytes and functions as a negatively regulator against bone mass by antagonizing low density lipoprotein receptor-related proteins- (LRP5-/LRP6-) mediated WNT/beta-catenin pathway signaling. Sclerostin levels are increased in the post-menopausal women and elderly and in long term immobilized patients. Sclerostin neutralizing antibody is reported to enhance bone formation, mass, and strength in aged male rats. Sclerostin and its inhibitors have potential in prosthetic, regenerative and preventive therapy in dentistry.

Specifications

• Antigen: Sclerostin
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Accession No.: Q9BQB4
• Host Species: Mouse
• Purification Method: Unpurified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Detects Sclerostin isoform 1 (UniProt Q9BQB4-1). Reactivity toward the spliced isoform 2 (UniProt Q9BQB4-2) is likely, but has not been determined.
• Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
• Isotype: IgG2b κ

• Applications: Immunohistochemistry, Western Blot
• Clone: 7B6.1
• Formulation: Mouse monoclonal IgG2bκ antibody tissue culture supernatant without preservatives.
• Gene Symbols: SOST
• Immunogen: GST-tagged recombinant protein corresponding to the internal fragment of human Sclerostin.
• Quantity: 200 μL
• Research Discipline: Signaling
• Gene ID (Entrez): NP_079513
• Target Species: Human, Rat
• Form: Supernatant

For Research Use Only