MilliporeSigma anti-Serotonin (5-HT) Transporter (602-622), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC177L100UL
Specifically detects Serotonin (5-HT) Transporter (602-622) Clone: in Mouse, Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immuno BlottingThe serotonin (5-hydroxytryptamine; 5-HT) transporter (5-HTT) plays an important role in the re-uptake of serotonin from the nerve terminal to ultimately terminate the serotonin signal. The 5-HTT plays a critical role in the regulation of serotonin neurotransmission, which has been linked to mood and personality disorders, anxiety, eating disorders, and insomnia. The predicted 12 transmembrane serotonin transporter contains potential sites for phosphorylation and glycosylation. Because serotonin is involved in such a variety of biological processes, the 5-HTT has been a target for the development of antidepressants and psychostimulants. Blocking serotonin uptake at the synapse has been achieved using structurally related chemicals called Selective Serotonin Re-uptake Inhibitors (SSRI) which alleviate disorders such as depression and alcoholism. The 5-HTT is localized to the plasma membrane of neurons and glial cells, as well as blood platelets, placenta, and endothelial cells.
|Serotonin (5-HT) Transporter (602-622)|
|a synthetic peptide corresponding to amino acids 602-622 of rat 5-HT transporter|
|Immuno Blotting, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen)|
|Recognizes the serotonin (5-HT) transporter in hypothalamus raphe nuclei and spinal cord.|
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